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In a study on the Japanese population, methamphetamine abusers with intermediate metaboliser (IM -*4/*10, *5/*10, *5/*14B, *10/*10, *10/*18, *10/*36, *10/*10xn ) phenotype carrying two or one reduced ( *10, *14B, *10xn ) and one non-functional allele ( *4, *5, *14A, *18, *36 ) predicted lower metabolism rate than extensive metaboliser (EM) phenotype carrying one or two functional alleles ( *1, *1xn, *2, *2xn ) based on urine and bone marrow autopsy samples [24]